Cortisol-3 [BSA]

Cortisol, BSAConjugated DAG2979 Lot. No. (See product label) PRODUCT INFORMATION Product overview Cortisol, BSAConjugated Description Cortisol BSA conjugate Position Cortisol3 Conjugate BSA Form Supplied in 0.015 M phosphate, 0.15 M NaCl, pH 7.2, 0.1% NaN3 Applications immunoassay development or other applications. Usage For Research Use Only. Not intended for diagnostic use. Suitable for use in immunoassay development or other applications. PACKAGING Storage Store at 28°C. short term and 20°C. long term Concentration 2.3 mg/ml BACKGROUND Introduction Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism. Keywords Cortisol; hydrocortisone; 11betahydrocortisone; AerosebHC; Alacort; barsebhc; Cleiton; component of Otalgine; Delacort REFERENCES 1. Coderre L, Srivastava AK, Chiasson JL (June 1991). "Role of glucocorticoid in the regulation of glycogen metabolism in skeletal muscle". Am. J. Physiol. 260 (6 Pt 1): E927–32. 2. Hennessy DP, Coghlan JP, Hardy KJ, Scoggins BA, Wintour EM (October 1982). "The origin of cortisol in the blood of fetal sheep". J. Endocrinol. 95 (1): 71–9. Creative Diagnostics. All rights reserved 4516 Ramsey Road Shirley, NY 11967, USA Tel: 6316244882 ·Fax:6316147828 Email: info@creativediagnostics.com www.creativediagnostics.com