HIV type 1 P24 [His]

Recombinant Human Immunodeficiency Virus Type 1 p24(Clade A), Histagged Cat.No:DAG2375 Lot. No. (See product label) PRODUCT INFOMATION species HIV Applications WB standard, antibody ELISA, immunogen, etc Storage Store at 4?C; DO NOT FREEZE; stable for 1 year from the date of shipment. Nonhazardous. No MSDS required Antigen Description Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV1) and HIV type 2 (HIV2). HIV1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV2 is related to viruses found in sooty mangabeys. HIV1 viruses may be further divided into groups. The HIV1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV1 group M subtypes are known to be more virulent or are resistant to different medications. HIV2 viruses are thought to be less virulent and transmissible than HIV1 M group viruses. Gag protein from HIV1 is a polyprotein, which, during viral maturation, is cleaved to release matrix p17, core p24 and nucleocapsid proteins. Capsid protein p24 forms the conical core that encapsulates the genomic RNAnucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is dissassembled soon after virion entry. The p24 antigen contains epitopes that prime helper CD4 Tcells, which have been demonstrated to be protective and it can elicit lymphocyte proliferation. p24 is likely to be an integral part of any multicomponent HIV vaccine. Concentration 1 mg/ml Source E. coli Tag His Form Each vial contains 100 μg of lyophilized protein in PBS. Purity >= 95% Dilutions Add 0.1 ml of ultrapure H2O to after receiving. Spin briefly before reconstitution. Background Introduction Human immunodeficiency virus (HIV) is a lentivirus (a member of the retrovirus family) that causes acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows lifethreatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, preejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. The four major routes of transmission are unsafe sex, contaminated needles, breast milk, and transmission from an infected mother to her baby at birth (perinatal transmission). Screening of blood products for HIV has largely eliminated transmission through blood transfusions or infected blood products in the developed world. Keywords HIV1 gp24; HIV1 gp24; Envelope surface glycoprotein gp24; Glycoprotein 24; gp24; gp24 glycoprotein; Human Immunodeficiency Virus 1; SU; Surface protein; Retroviridae; Lentivirus; human immunodeficiency virus Creative Diagnostics. All rights reserved 4516 Ramsey Road Shirley, NY 11967, USA Tel: 6316244882 ·Fax:6316147828 Email: info@creativediagnos