HPV type 3

SPECIFICATION SHEET Rev 111114AGZMZ003 Inactivated Human Parainfluenza Virus 3 Antigen Antigen (HPIV 3) Cat. No: DAG207 Lot.No: (See product label) PRODUCT INFORMATION BACKGROUND Product Overview: Inactivated Human Parainflu Introduction: HPIV is genetically and antigenically enza Virus 3 Antigen is inactivated using gamma divided into types 1 to 4. HPIV 1 to HPIV 3 are major radiation. causes of lower respiratory infections in infants, young Target Species: Viral children, the immunocompromised, the chronically ill, Activity: This product has been rendered inactive by and the elderly. Each subtype can cause somewhat standard procedures. However this material should unique clinical diseases in different hosts. HPIV are still be handle Infectious and should be disposed of enveloped and of medium size (150 to 250 nm), and appropriately. their RNA genome is in the negative sense. These Format: Inactivated Pathogen viruses belong to the Paramyxoviridae family, one of Product Form: Inactivated Parainfluenza virus 3 the largest and most rapidly growing groups of viruses liquid causing significant human and veterinary disease. Preparation: Optimally infected monolayers are har HPIV are closely related to recently discovered mega vested, disrupted by sonication and subjected to low myxoviruses (Hendra and Nipah viruses) and metap speed centrifugation. The clarified cell lysate is neumovirus. pooled with supernatant from the infected culture Key words: HPIV3; Human Parainfluenza Virus 3; and concentrated using crossflow ultrafiltration. The Human parainfluenza viruses; HPIVs; HPIV3; Parain antigen preparation is inactivated using gamma ra fluenza 3 virus; PIV3; Paramyxoviridae diation. Applications: ELISA REFERENCES PACKAGING 1. Sato M, Wright PF (October 2008). "Current status of vaccines for parainfluenza virus infec Buffer Solution: Tissue Culture Media tions". Pediatr. Infect. Dis. J. 27 (10 Suppl): S123 Preservative Stabilisers: None present –5. Approx. Protein Concentrations: 1.58 mg/ml 2. Sable CA, Hayden FG (December 1995). Shelf Life: 18 months from date of despatch. "Orthomyxoviral and paramyxoviral infections in Storage: Store at 70°C. Storage in frost free freez transplant patients". Infect. Dis. Clin. North Am. 9 ers is not recommended. This product should be (4): 987–1003. stored undiluted. Avoid repeated freezing and thaw ing as this may denature the protein. Creative Diagnostics. All rights reserved. 4516 Ramsey Road Shirley, NY 11967, USA Tel: 6316244882 ·Fax:6316147828 Email: info@creativediagnostics.com www.creativediagnostics.com