HPV type 1
SPECIFICATION SHEET
Rev 111114AGZMZ001
Inactivated Human Parainfluenza Virus 1 Antigen
Antigen (HPIV1)
Cat. No: DAG205
Lot.No: (See product label)
PRODUCT INFORMATION BACKGROUND
Product Overview: Inactivated Human Parainflu Introduction: HPIV is genetically and antigenically
enza Virus 1 Antigen is inactivated using gamma divided into types 1 to 4. HPIV 1 to HPIV 3 are major
radiation. causes of lower respiratory infections in infants, young
Target Species: Viral children, the immunocompromised, the chronically ill,
Activity: This product has been rendered inactive by and the elderly. Each subtype can cause somewhat
standard procedures. However this material should unique clinical diseases in different hosts. HPIV are
still be handle Infectious and should be disposed of enveloped and of medium size (150 to 250 nm), and
appropriately. their RNA genome is in the negative sense. These
Format: Inactivated Pathogen viruses belong to the Paramyxoviridae family, one of
Product Form: Inactivated Parainfluenza virus 1 the largest and most rapidly growing groups of viruses
liquid causing significant human and veterinary disease.
Preparation: Optimally infected monolayers are har HPIV are closely related to recently discovered mega
vested, disrupted by sonication and subjected to low myxoviruses (Hendra and Nipah viruses) and metap
speed centrifugation. The clarified cell lysate is neumovirus.
pooled with supernatant from the infected culture Key words: HPIV1; Human Parainfluenza Virus 1;
and concentrated using crossflow ultrafiltration with a Human parainfluenza viruses; HPIVs; HPIV 1; hPIV1;
30,000 molecular weight cutoff. The antigen prepara Human parainfluenza 1 virus; Human parainfluenza
tion is inactivated using gamma radiation. virus type; Parainfluenza; Parainfluenza Type 1; Para
Applications: ELISA myxoviridae
PACKAGING REFERENCES
Buffer Solution: Tissue Culture Media 1. Sato M, Wright PF (October 2008). "Current
Preservative Stabilisers: None present status of vaccines for parainfluenza virus infec
Approx. Protein Concentrations: Total protein tions". Pediatr. Infect. Dis. J. 27 (10 Suppl): S123
concentration 2.25 mg/ml –5.
Shelf Life: 18 months from date of despatch. 2. Sable CA, Hayden FG (December 1995).
Storage: Store at 70°C. Storage in frost free freez "Orthomyxoviral and paramyxoviral infections in
ers is not recommended. This product should be transplant patients". Infect. Dis. Clin. North Am. 9
stored undiluted. Avoid repeated freezing and thaw (4): 987–1003.
ing as this may denature the protein.
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