Digoxin [FITC]

SPECIFICATION SHEET Rev 111113AGMYX0027 Digoxin, FITC Conjugated Antigen (Digoxin) Cat. No: DAG172 Lot.No: (See product label) PRODUCT INFORMATION BACKGROUND Product Overview: Digoxin is a glycoside extracted from the Introduction: Digoxin INN also known as digitalis, is a purified foxglove plant Digitalis lanata. Purification by preparative thin cardiac glycoside and extracted from the foxglove plant, Digi layer chromatography (TLC). talis lanata. Its corresponding aglycone is digoxigenin, and its Product Form: Digoxin conjugated to Fluorescein Isothiocy acetyl derivative is acetyldigoxin. Digoxin is widely used in the anate (FITC) liquid treatment of various heart conditions, namely atrial fibrillation, Approx. Protein Concentrations: 10 µmol/L Determined atrial flutter and sometimes heart failure that cannot be con by measurement of the optical density of the fluorescein trolled by other medication. Digoxin preparations are com group. monly marketed under the trade names Lanoxin, Digitek, and Applications: Immunoassay Lanoxicaps. It is also available as a 0.05 mg/mL oral solution and 0.25 mg/mL or 0.5 mg/mL injectable solution. It is mar PACKAGING keted by GlaxoSmithKline and many other pharmaceutic manufacturers. Digoxin’s primary mechanism of action is to Buffer Solution: Ethanol inhibit alpha subunits of the Na+/K+ ATPase pump located in Preservative Stabilisers: None present. the plasma membrane of human myocytes. Digoxin also re Shelf Life: 12 months from date of despatch. sults in a decrease of electrical impulse conduction through Storage: Store at 20°C only. Storage in frostfree freezers is the AV node. not recommended. This product should be stored undiluted. Keywords: (3beta,5beta,12beta)3((o2,6dideoxybetad This product is photosensitive and should be protected from ribohexapyranosyl(14)2,6dide; 12,14dihydroxycard20 light. Avoid repeated freezing and thawing as this may dena (22)enolide; 14dihydroxy,(3beta,5beta,12beta)xopyranosyl) ture the antigen. Should this product contain a precipitate we oxy]1; 14dihydroxy,(3beta,5beta,12beta)y)1; 2,6dideoxy recommend microcentrifugation before use. betadribohexopyranosyl(1.fwdarw.)2,6dideoxybetadribo he; acygoxin; card20(22)enolide,3((o2,6dideoxybetad ribohexopyranosyl(14)o2,6di; card20(22)enolide,3[(o 2,6dideoxybetadribohexopyranosyl(1.fwdarw.)o; car doxin; chloroformicdigitalin; cordioxil; davoxin; deoxybetad ribohexopyranosyl(14)2,6dideoxybetadribo hexopyranosyl)ox; digitalis; digitalisglycoside; digoksyna; digo nix; digosin; digoxigenintridigitoxosid; digoxine; dilanacin; dixina; dokim; dynamos; homolle’sdigitalin; lanatilin; lanicor; lanocardin; lanoxicaps; lenoxicaps; lenoxin; longdigox; neodi oxanin; oxybetadribohexopyranosyl(14)2,6dideoxybeta dribohexopyranosyl)oxy); rougoxin; saroxin; skdigoxin; stilla cor; DIGACIN; DIGOXIN, AP; DIGOXIN; LANACORDIN; LANOXIN; 20(22),5BETACARDENOL