Dapsone [HRP]

Dapsone, HRP conjugate DAG1079 Lot. No. (See product label) PRODUCT INFORMATION Product overview Dapsone, HRP conjugate Antigen Description A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. Source NSAIDs Conjugate HRP Form concentrate Characteristic Each conjugate comprises antigen covalently bound to horseradish peroxide and is suitable as a tracer in immunoassay development PACKAGING Storage Can be stored at 28°C for up to 3 months and at 20°C for longer term storage. BACKGROUND Introduction Dapsone (diaminodiphenyl sulfone) is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). It is also secondline treatment for prophylaxis (prevention) against Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly P. carinii) in HIV patients in whom CD4 counts are below 200/mm3. Keywords Dapsone; 4[(4aminobenzene)sulfonyl]aniline; Acedapsone; 4Aminophenylsulphone; 4,4’sulfonylbis Benzenamine; DADPS; AVLOSULFON; SULPHADIONE REFERENCES 1. Begon E, Chosidow O, Wolkenstein P (December 2004). "[Disulone]" (in French). Ann Dermatol Venereol 131 (12): 1062–73. DOI:10.1016/S01519638(04)938422. PMID 15692440. 2. Uetrecht JP (1995). "Myeloperoxidase as a generator of drug free radicals". Biochem. Soc. Symp. 61: 163–70. PMID 8660393. Creative Diagnostics. All rights reserved 4516 Ramsey Road Shirley, NY 11967, USA Tel: 6316244882 ·Fax:6316147828 Email: info@creativediagnostics.com www.creativediagnostics.com