Rabbit Anti-Human AR Polyclonal Antibody, Phospho-Ser213

Rabbit AntiAR Polyclonal Antibody CPB681RH Rabbit(AR) Lot. No. (See product label) PRODUCT INFORMATION Product Overview Rabbit AntiAR Polyclonal Antibody Antigen Description The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the Nterminal domain, DNAbinding domain, and androgenbinding domain. The protein functions as a steroidhormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. specificity The antibody detects endogenous level of Androgen Receptor only when phosphorylated at serine 213. Target AR Immunogen Peptide sequence around phosphorylation site of serine 213(EAS(p)GA) derived from Human Androgen Receptor. Host Rabbit Species Human Cross Reactivity Human conjugation N/A Applications IFA,WB PACKAGING Format Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. Storage Store at 20°C /1 year ANTIGEN GENE INFORMATION Gene Name AR androgen receptor [ Homo sapiens ] Official Symbol AR Synonyms AR; androgen receptor; DHTR, dihydrotestosterone receptor , SBMA, spinal and bulbar muscular atrophy; AIS; HUMARA; Kennedy disease; NR3C4; SMAX1; testicular feminization; dihydrotestosterone receptor; androgen nuclear receptor variant 2; nuclear receptor subfamily 3 group C member 4; KD; TFM; DHTR; SBMA; HYSP1; GeneID 367 mRNA Refseq NM_000044 Protein Refseq NP_000035 MIM 313700 UniProt ID P10275 Chromosome Location Xq12 Creative Diagnostics. All rights reserved 4516 Ramsey Road Shirley, NY 11967, USA Tel: 6316244882 ·Fax:6316147828 Email: info@creativediagnostics.com www.creativediagnostics.com Pathway Alpha6Beta4 Integrin Signaling Pathway, organismspecific biosystem; Androgen Receptor Signaling Pathway, organismspecific biosystem; Coregulation of Androgen receptor activity, organismspecific biosystem; FOXA1 transcription factor network, organismspecific biosystem; Gene Expression, organismspecific biosystem; Generic Transcription Pathway, organismspecific biosystem; IL6 Signaling Pathway, organismspecific biosystem; Function DNA binding; DNA binding; POU domain binding; androgen binding; androgen receptor activity; androgen receptor activity; androgen receptor activity; androgen receptor activity; androgen receptor activity; androgen receptor binding; betacatenin binding; betacatenin binding; betacatenin binding; chromatin binding; enzyme binding; ligandactivated sequencespecific DNA binding RNA polymerase II transcription factor activity; metal ion binding; protein binding; protein dimerization activity; receptor activity; receptor binding; sequencespecific DNA binding; sequencespecific DNA binding transcription factor activity; steroid binding; transcription factor binding; transcription regulatory region D