EX-527

In Stock EX-527 Find a Distributor Specifications Protocol & Docs Background Features Selective SIRT1 inhibitor Does not inhibit HDACs Inhibitor of SIRT1 deacetylation of p53 Personal Touch Here to Help. Ready to Ship Most kits in stock. Easy to Use Simple protocols. Documents Product Protocol Product SDS EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM in vivo, 38nM in vitro) that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 20 uM, 49 uM, > 100 uM and > 100 uM for SIRT2, SIRT3, HDAC and NADase respectively). EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage. Enlarge image Enlarge image Contact Us Email Technical Support Resources