Recombinant TRMT61A protein

PDGFRA (Platelet Derived Growth Factor Receptor Alpha), a tyrosine-protein kinase that acts as a cell surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival, and chemotaxis. Depending on the context, PDGFRA promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRA phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca (2+) and the activation of protein kinase C. PDGFRA phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. This protein also mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1 and promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B.