Recombinant SETD1B-SET complex

PTK6 is a non-receptor tyrosine-protein kinase which implicated in the regulation of a variety of signaling pathways and control the differentiation and maintenance of normal epithelia, as well as tumor growth. Its function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. It also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. PTK6 also contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/ p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS.