Recombinant SETD4 protein

PRDM1 (PR/SET Domain 1), also called as Beta-Interferon Gene Positive-Regulatory Domain I Binding Factor, or BLIMP1, is a transcription factor that acts as a repressor of beta-interferon gene expression. It mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. PRDM1 plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity).