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Ribonuclease H (250u)

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M4285

Description

Ribonuclease H (RNase H) is an endonuclease that specifically hydrolyzes the phosphodiester bonds of RNA hybridized to DNA to produce 3´-OH and 5´-P-terminated products. It will not degrade single-stranded nucleic acids, double-stranded DNA or double-stranded RNA.

Applications

  • Removal of the RNA strand prior to second-strand cDNA synthesis.
  • Analysis of in vitro polyadenylation reaction products.
  • Microarrays.

References

  1. Goodwin, E.C. and Rottman, F.M. (1992) Nucl. Acids Res. 20, 916.

Specifications

QC Tests

Activity, DNase, RNase, endonuclease, cDNA synthesis.

Source

Recombinant E. coli strain.

Storage Buffer

20mM HEPES-KOH (pH 7.8 at 25°C), 1mM DTT, 50mM KCl, 50% (v/v) glycerol, 0.2mg/ml BSA.

Storage Conditions

Store at –20°C.

Unit Definition

One unit is defined as the amount of enzyme required to produce 1nmol of acid-soluble ribonucleotides from radiolabeled poly(rA):poly(dT) in 20 minutes at 37°C in 20mM HEPES-KOH (pH 7.8), 50mM KCl, 10mM MgCl2, 1mM DTT, 20μM radiolabeled poly(rA):poly(dT).

For product intended use please see Patents & Disclaimers tab.

Protocols and manuals

Resources

Use Restrictions

M4281, M4285 For Laboratory Use. Outside of the United States, this product is intended for research use only unless otherwise stated.

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