Aurora B (
Aurora Kinase B,
AurB,
ARK2) is a Ser/Thr kinase that is part of the chromosomal passenger complex that associates with chromosomes and is an important regulator of mitosis and meiosis.
Aurora B becomes concentrated at the centromere during the onset of mitosis, but relocates to the spindle midzone during anaphase.
Aurora B phosphorylates a number of substrates, including
INCENP, CENP-A, and
Histone H3. Misregulation of
Aurora B activity can lead to chromosome instability and is implicated in a number of cancers.
Aurora B (
Aurora Kinase B,
AurB,
ARK2) is a Ser/Thr kinase that is part of the chromosomal passenger complex that associates with chromosomes and is an important regulator of mitosis and meiosis.
Aurora B becomes concentrated at the centromere during the onset of mitosis, but relocates to the spindle midzone during anaphase.
Aurora B phosphorylates a number of substrates, including
INCENP, CENP-A, and
Histone H3. Misregulation of
Aurora B activity can lead to chromosome instability and is implicated in a number of cancers.
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